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Los Angeles Rams vs San Francisco 49ers Best Bets and Betting Odds | NFL Week 4 2022

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The San Francisco 49ers (1W-2L) will go head-to-head with the Los Angeles Rams (2W-1L) in Santa Clara on Monday, October 3 at Levi’s Stadium. No doubt each of these rivals will be searching for a win, so don’t forget to place your bets and then catch the excitement live at 5:15 PM PT!

For context related to this matchup, how have the 49ers and the Rams performed versus each other in the past? While the teams have played in nine contests over the past few years, the home team, the 49ers, have claimed victory six times against their opponents. In their most recent meeting on January 30, 2022, the score was 20-17 in favor of the Los Angeles Rams.

Betting Preview for the Los Angeles Rams vs San Francisco 49ers NFL Week 4 Game on October 3 2022

Where: Levi’s Stadium in Santa Clara, California

When: Monday, October 3, 2022 at 5:15 PM PT

Betting on the Los Angeles Rams

Regular Season Record: (2W-1L) | National Football Conference Standing: 2

In their most recent game on Sunday, September 25, 2022, the Rams beat the Arizona Cardinals 12-20.

Absences and Injuries

Regarding inactive players, the Rams are without Troy Hill (Groin), Brian Allen (Knee), Tremayne Anchrum (Lower Leg), David Edwards (Illness), Travin Howard (Groin), Van Jefferson (Knee), Xavier Jones (Achilles), David Long (Groin), Logan Bruss (Knee – ACL + MCL), Decobie Durant (Hamstring), Daniel Hardy (Ankle), Quentin Lake (Knee), and Kyren Williams (Ankle).

Betting on the San Francisco 49ers

Regular Season Record: (1W-2L) | National Football Conference Standing: 10

In their most recent game on Sunday, September 25, 2022, the 49ers lost to the Denver Broncos 11-10.

Absences and Injuries

With respect to inactive players in this game, the 49ers will play without Tyler Kroft (Knee – MCL), Azeez Al-Shaair (Knee – MCL), Arik Armstead (Foot), Ross Dwelley (Ribs), Maurice Hurst Jr. (Biceps), Javon Kinlaw (Knee), Trey Lance (Ankle), Jordan Matthews (Knee – ACL), Elijah Mitchell (Knee – MCL), Tarvarius Moore (Hamstring), Jason Verrett (Knee – ACL), Jimmie Ward (Hamstring), Trent Williams (Ankle), Jordan Willis (Undisclosed), Curtis Robinson (Ankle), Kalia Davis (Undisclosed), and Danny Gray (Hip).

Los Angeles Rams vs San Francisco 49ers | Moneyline, Over/Under and Point Spread Odds

Moneyline Pick: San Francisco 49ers (-122) at FanDuel

The San Francisco 49ers are considered the favorite by many football fans and oddsmakers. The team goes into the matchup with a winning percentage of 33%. Comparatively, the Los Angeles Rams’ winning percentage is 67%.

Over/Under Pick: Over 42.5 Points (-110) at FanDuel

The San Francisco 49ers have recorded an average of 15.67 points per game during the regular season. The Los Angeles Rams have recorded 20.33 points.

Spread Pick: Los Angeles Rams 1.5 Points (-110) at FanDuel

The Los Angeles Rams will need to lose by less than the amount of the spread or win outright in order to cover.

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