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Indianapolis Colts vs Denver Broncos Predictions, Picks, Odds, and Betting Preview | NFL Week 5 2022

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The Denver Broncos play the Indianapolis Colts during the second half of an NFL football game, Sunday, Oct. 27, 2019, in Indianapolis. (AP Photo/AJ Mast)

With the pressing need to get back to winning ways, Colts vs. Broncos are in charge of opening the fifth week of the NFL with the match scheduled for Thursday Night Football.

Indianapolis suffered its second loss of the season on Sunday after being defeated 24-17 by the Titans, while Denver was comfortably beaten, thanks to a 23-32 score, by the Raiders. Without further ado, at JefeBet we leave you with the best preview of the Indianapolis Colts vs Denver Broncos game.

Predictions and Betting Preview for the Indianapolis Colts vs Denver Broncos NFL Week 5 Game on October 6, 2022

Colts vs Broncos Predictions Picks Betting Odds
  • Where: Empower Field at Mile High – Denver, Colorado.
  • When: Thursday, October 6, 2022, 8:15 PM E.T.

Odds courtesy of BetMGM.

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Betting on the Indianapolis Colts

Colts vs Broncos Predictions Picks Betting Odds
  • Season record: 1-2-1.
  • BetMGM Spread: +3.5.
  • Moneyline: (+150)
  • Over/Under: 43.5

Following a convincing victory over the Chiefs in Week 3, the Colts were unable to capitalize on their home-field advantage, making mistakes that cost them the game against Tennessee.

Matt Ryan’s 356 yards through the air and two touchdowns did little good because of three turnovers committed by the Colts, two of them by the quarterback himself. The Titans took full advantage of an interception and a fumble from Ryan, which they capitalized on with two touchdowns on the next offensive series.

Also, in the fourth quarter, with the game within seven points, running back Jonathan Taylor dropped a fumble almost in the red zone to end any chance of a comeback.

Defensively, beyond the 24 points accepted, Indianapolis did another solid job as 14 of them came after the offense’s two turnovers in tough territory. The Colts conceded just 243 total yards and did not allow a single Titans point in the second half. In the face of Denver’s banged up offense, this performance could hold up.

Betting on the Denver Broncos

Colts vs Broncos Predictions Picks Betting Odds
  • Season record: 2-2.
  • BetMGM Spread: -3.5.
  • Moneyline: (-185).
  • Over/Under: 43.5

The Broncos’ situation is complex for many reasons. In addition to being defeated by the Raiders and leaving their record even, their second running back, Javonte Williams, will miss the remainder of the season due to ruptured knee ligaments.

This is a very painful loss for a Denver offense that is still not performing as well as expected after the arrival of Russell Wilson. The quarterback added two touchdown passes on Sunday, but for the third consecutive week failed to gain even 250 yards through the air (237). Denver also failed to surpass 300 total yards (299) for the second week in a row, and also added a fumble that ended in a 68-yard touchdown return.

The defense didn’t have an easy night in Las Vegas either. For the first time this season, they conceded more than 17 points in a game; meanwhile, the Raiders totaled 385 total yards, with 25 first downs and no turnovers. The good news is that they won both of their home games in 2022, and none of their opponents scored more than 10 goals.

JefeBet Prediction

Given both teams’ offensive performances and their need to get a win, we should expect a good defensive matchup next Thursday at The High Mile.

The Broncos’ defense is much better than the one that played in Las Vegas, and the Colts haven’t conceded more than 24 points this year, a number that is currently high for Denver’s offense. The under has been the winning bet in three of the last five meetings between them; moreover, in the last nine Indianapolis meetings in general, the game ended with the under.

Prediction: Under (IND 17 – DEN 21).


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