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Arizona Cardinals vs Cincinnati Bengals Predictions, Picks, Odds, and Betting Preview | NFL Preseason Week 1 2022

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FILE - In this Oct. 6, 2019, file photo, Arizona Cardinals quarterback Kyler Murray (1) leaps in for a touchdown against Cincinnati Bengals cornerback William Jackson (22) in the first half of an NFL football game, in Cincinnati. Murray went to Arizona with the top pick a year after the Cardinals used a first-rounder on Josh Rosen and has lived up to the billing. Murray has thrown for 2,866 yards while starting every game, has thrown for 14 TDs compared to only six interceptions, and has rushed for 446 yards and four scores. (AP Photo/Gary Landers, File)

The Arizona Cardinals and Cincinnati Bengals’ NFL preseason officially begins on August 12 with a matchup that will help both teams begin to showcase their weapons against a talented opponent.

On the Cardinals’ side, all eyes will be on quarterback Kyler Murray, who is in the midst of contract extension negotiations with the organization, while the Bengals are facing a challenging season after reaching the Super Bowl.

Cardinals vs Bengals Predictions Picks Betting Odds

Predictions and Betting Preview for the Arizona Cardinals vs Cincinnati Bengals NFL Preseason Week 1 Game on August 12, 2022

  • Where: Paul Brown Stadium – Cincinnati, Ohio.
  • When: Friday, August 12, 2022, 7:30 PM E.T.

Betting on the Arizona Cardinals

Cardinals vs Bengals Predictions Picks Betting Odds
  • Record: 0-0
  • Spread: +2.5
  • Moneyline: -110
  • Over/Under: 33.5

The Arizona Cardinals are one of the clubs that have raised the most doubts among NFL analysts this season, following a disappointing preseason in which they lost more players than they were able to sign.

Meanwhile, for this game against the Bengals, the quarterback Kyler Murray will be under the spotlight pending his contract status, and how he will work with his new catcher and friend, Marquise Brown, who arrived from the Ravens as the organization’s big acquisition.. All this in the face of a fairly solid Cincinnati defense that did not suffer many changes.

On the defensive side of the ball, there is also a lot of doubt after Chandler Jones, the team’s leader in catches last year, left. Arizona needs J.J. Watt to remain healthy and their defense to improve, which they might begin to do against one of the greatest quarterbacks on the circuit in Joe Burrow.

Betting on the Cincinnati Bengals

Cardinals vs Bengals Predictions Picks Betting Odds
  • Record: 0-0
  • Spread: -2.5
  • Moneyline: -110
  • Over/Under: 33.5

With the same core team that made a splash last season by reaching the Super Bowl, the Bengals begin a new NFL journey against a rather unpredictable Arizona team.

Joe Burrow will once again be at the helm of an offense that kept its weapons on the second line and looked to bolster its first offensive line, which allowed the most catches last season. It is precisely that area of the game that they could begin to consolidate against the Cardinals, a team that projects to have a lot of trouble pressuring the opposing QB.

On defense, the Bengals had to bolster their secondary with draft picks after the departure of several big names. Those young stars will get an early look at quality quarterbacks when they face the multi-faceted Murray.

JefeBet Prediction

While the Cardinals are a team that has talent, the Bengals appear to have a pretty solid core with a quarterback who has his mind on the gridiron and not on a contract situation. For this game, the Bengals will win 21-14.


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Written by Henry Roldán

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