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2022 NFL Week 10 | Predictions, Odds and Betting Previews for all Games

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FILE - Fans watch during the first half of an NFL football game between the San Francisco 49ers and the Carolina Panthers at Levi's Stadium in Santa Clara, Calif., Sunday, Sept. 10, 2017. There are 23 venues bidding to host soccer matches at the 2026 World Cup in the United States, Mexico and Canada. (AP Photo/Tony Avelar, File)

The 9th week of the current 2022 season has gone by with important definitions across the league. Now that NFL Week 10 is almost here, we know that the season is drawing to a close. As usual, JefeBet brings you the best predictions for all games to be played this week.

There will be 14 games played between November 10 and November 14, taking into account that the Baltimore Ravens, Cincinnati Bengals, New England Patriots and New York Jets are taking the week off. Without further ado, here are our predictions for NFL Week 10.

All odds shown are courtesy of BetMGM.

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Predictions, Odds and Betting Preview for 2022 NFL Week 10 Games

Atlanta Falcons (-150) vs Carolina Panthers (+125) / Thursday, November 10 / 8:15 PM E.T.

NFL Week 10 Predictions Picks Betting Odds
  • Falcons Spread: -3.0.
  • Panthers Spread: +3.0.
  • Over/Under: 42.5

NFL Week 10 kicks off this Thursday with Thursday Night Football between NFC South rivals Falcons and Panthers.

Atlanta lost its lone division lead Sunday, falling to the Chargers 20-17 to drop its record to 4-5. The team failed to capitalize on the strong performance of its defense, after Los Angeles turned the game around with six points in the fourth quarter on the strength of two field goals, including a 37-yarder with no time on the clock.

For their part, the Panthers were crushed 21-42 by the Bengals and with a record of 2-7 are the first team in the league to reach that number of defeats. Carolina’s defense has committed the most penalties this year and has conceded the most points. On offense, the return of quarterback Baker Mayfield is great news as the team prepares to face the Falcons for the second time in three weeks.

Prediction: Falcons spread.

[Falcons vs Panthers NFL Week 10 full betting preview here]

Seattle Seahawks (+115) vs Tampa Bay Buccaneers (-140) / Sunday, November 13 / 9:30 AM E.T.

NFL Week 10
  • Seahawks Spread: +2.5.
  • Buccaneers Spread: -2.5.
  • Over/Under: 44.5.

This Sunday’s meeting between the Seahawks and Buccaneers will go down in NFL history as the two will be the first to play a regular round game in Germany, specifically at the Allianz Arena in Munich.

The Seahawks are one of the pleasant surprises of the season as they lead the NFC West with a 6-3 record after their 31-21 win over the Cardinals. Seattle’s offense is among the best in the NFL, second only to the Chiefs in points scored, while its defense has been improving and in the last four games hasn’t allowed more than 23 touchdowns.

As for Tampa Bay, they are coming off a three-game losing streak with a 13-16 win over the Rams and remain co-leaders of the NFC South, the league’s most mediocre division, with a 4-5 record. After scoring nine points in four quarters, Tom Brady made up for his team’s performance by leading a winning offensive series that led them to win again, although in the last four games they have topped 20 points only once.

Prediction: Seahawks to win (SEA 23 – TB 20).

[Seahawks vs Buccaneers NFL Week 10 full betting preview here]

Denver Broncos (+125) vs Tennessee Titans (-150) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Broncos Spread: +3.0.
  • Titans Spread: -3.0.
  • Over/Under: 39.

The Broncos return from their bye week with a very interesting matchup against the Titans in NFL Week 10.

After a 21-17 win over the Jaguars in their last game to bring their record to 3-5, Russell Wilson and company could define their future this season in a very tough matchup against Tennessee. Despite being the defense that concedes the lowest average yards per play to its opponents, there have been serious and consistent problems regarding the offense in Wilson’s first season at the helm of the team.

As for the Titans, they remain atop the AFC South with a 5-3 record despite Monday’s 17-20 overtime loss to the Chiefs. After a difficult start to the season, before losing to Kansas City, the Tennessee team had won five straight victories by conceding no more than 17 points to their opponents in that span. Derrick Henry also bounced back and the Titans have six 100+ yards on the ground, including a 314-yarder against the Texans.

Prediction: Under.

[Broncos vs Titans NFL Week 10 full betting preview herecomma]

Cleveland Browns (+165) vs Miami Dolphins (-200) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Browns Spread: +4.0.
  • Dolphins Spread: -4.0.
  • Over/Under: 48.5

On Sunday, the Browns will play the Dolphins in another crucial AFC playoff clash.

Cleveland has just returned from their bye week, previous to which they defeated the Bengals 13-32. With a 3-5 record, the Browns must rely on their good ground attack to defeat the Dolphins, who are currently the owners of one of the AFC wild cards but with a lot of defensive problems.

Miami is coming off a 35-22 win over the Bears last weekend and remains on top of the AFC East with a 6-3 record. With the return of Tua Tagovailoa, the Dolphins are positioned as one of the best passing offenses in the league, something that has helped them alleviate the defensive problems that have plagued them in recent weeks.

Prediction: Over.

[Browns vs Dolphins NFL Week 10 full betting preview here]

New Orleans Saints (-145) vs Pittsburgh Steelers (+120) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Saints Spread: -2.5.
  • Steelers Spread: +2.5.
  • Over/Under: 41.5.

Two teams with negative records meet this Sunday when the Saints must visit the Steelers in an interconference matchup.

Despite falling to a 3-6 record with Monday Night’s 27-13 loss to Baltimore, New Orleans remains in contention in the NFC North, where all of its teams have losing records. The Saints were thoroughly outplayed by the Ravens and for the first time since Week 3 failed to score more than 20 points. The defense struggled again and despite the shutout against the Raiders last week, for the sixth time they conceded more than 26 goals to their opponents.

The Steelers, meanwhile, are coming off a bye week and will be looking to snap a two-game losing streak at home, which they extended with a 13-35 loss to the Eagles. Pittsburgh is one of the worst offenses in the circuit, surpassing 20 points on only three occasions, and against the Saints’ defense could have its best night despite being practically eliminated from any postseason competition.

Prediction: Over.

[Saints vs Steelers NFL Week 10 full betting preview here]

Detroit Lions (+130) vs Chicago Bears (-155) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Lions Spread: +3.0.
  • Bears Spread: -3.0.
  • Over/Under: 48.5

When the Lions and Bears meet for the first time this season, the bottom of the NFC North will be decided.

Detroit snapped a five-game losing streak Sunday by beating the Packers 9-15 to drop its record to 2-6. This was undoubtedly the Lions’ best defensive game, allowing less than 24 points to an opponent for the first time and adding three interceptions to Aaron Rodgers. The offense also struggled, recording less than 330 yards for the first time, but it was enough for the win.

As for the Bears, they were defeated for the second consecutive week when they were unable to defeat the Dolphins at home by a score of 35-32. Chicago’s offensive problems appear to be over with three straight weeks of scoring 29 + points; however, the defense has allowed 35 + points in two straight games despite not allowing 20 + in five of their first seven games.

Prediction: Under.

[Lions vs Bears NFL Week 10 full betting preview here]

Minnesota Vikings (+260) vs Buffalo Bills (-350) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Vikings Spread: +7.5.
  • Bills Spread: -7.5.
  • Over/Under: 46.5.

The NFL’s most high-profile Week 10 matchup takes place next Sunday afternoon when the Vikings and Bills meet.

Minnesota kept its six-game winning streak with a 17-20 victory over the Commanders and solidified its lead in the NFC North with a 7-1 record. The Vikings rallied from a 13-point deficit in the fourth quarter, highlighted by a Greg Joseph field goal with 12 seconds remaining. Defensively, they allowed just 263 yards and with one interception have now forced opponents into turnovers in every game this season.

Meanwhile, Buffalo remains the leader of the tough AFC East despite a 17-20 loss to the Jets. Josh Allen and company had one of their most difficult games:for the first time this season, they failed to total more than 200 passing yards. The defense was again up to the task, but the offense lost two balls for the second consecutive week.

Prediction: Vikings Spread.

[Vikings vs Bills NFL Week 10 full betting preview here]

Houston Texans (+240) vs New York Giants (-300) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Texans Spread: +6.5.
  • Giants Spread: -6.5.
  • Over/Under: 39.5.

Two teams with very different realities will face off this Sunday when the Texans pay a visit to the Giants in the Big Apple.

For the third consecutive week, the Texans were defeated, this time losing 29-17 to the Eagles, the only undefeated team in the league. Houston’s offense is one of the weakest in all of the NFL and have barely surpassed 20 points on one occasion this season. With that kind of performance, there is little any defense can do to prevent their team from a 1-6-1 record and being at the bottom of the AFC South.

As for the Giants, they return to action after heading into their bye week with a 13-27 loss to the Seahawks in Week 8. New York is one of the owners of the NFC wild cards with a 6-2 record, and their game against Seattle was the only one that has been decided by more than eight points.

Prediction: Giants to win.

[Texans vs Giants NFL Week 10 full betting preview here]

Jacksonville Jaguars (+350) vs Kansas City Chiefs (-450) / Sunday, November 13 / 1:00 PM E.T.

NFL Week 10
  • Jaguars Spread: +9.5.
  • Chiefs Spread: -9.5.
  • Over/Under: 50.5

On Sunday afternoon, the Jaguars and Chiefs will square off in an American Conference showdown between two teams with very different goals.

After five consecutive losses, the Jacksonville team returned to winning ways with a 20-27 victory over the Raiders, leaving them with a 3-6 record. With their fourth game of the season with more than 400 total yards and aided by two touchdowns on the ground by Travis Etienne Jr., the Jaguars came from behind despite a 17-0 start and will now be looking to pull off an upset against the Chiefs before heading into their bye week.

Kansas City remains the leader of the AFC West with a 6-2 record after defeating the Titans 17-20 in overtime. Patrick Mahomes was the star of his team, throwing for 466 yards and running for another 63, in addition to two TDs in total. The defense also had a good night, allowing just 229 total yards and only 57 passing yards.

Prediction: Chiefs spread.

[Jaguars vs Chiefs NFL Week 10 full betting preview here]

Indianapolis Colts (+200) vs Las Vegas Raiders (-250) / Sunday, November 13 /4:05 PM E.T.

NFL Week 10
  • Colts Spread: +6.0.
  • Raiders Spread: -6.0.
  • Over/Under: 42.5

As part of the NFL Week 10 schedule, the Colts and Raiders will square off in a showdown between two of the most disappointing teams of the current season.

After losing for the third consecutive week, 3-26, to the Patriots, the Indianapolis team will play Sunday with a new head coach following the firing of Frank Reich. The Colts have been a real disaster, especially on offense, where they have failed to score more than 10 points three times this season. In this way, Jeff Saturday will take a team with a 3-5-1 record and second place in the AFC South.

As for Las Vegas, for the third time this season, they squandered a lead of at least 17 points to lose 20-27 to the Jaguars, dropping to 2-6. The Raiders’ Achilles heel has been inconsistency. They were built to make the playoffs under coach Josh McDaniels, but they are currently in bottom of the division with little prospect of improving.

Prediction: Raiders to win.

[Colts vs Raiders NFL Week 10 full betting preview here]

Dallas Cowboys (-225) vs Green Bay Packers (+180) / Sunday, November 13 / 4:25 PM E.T.

NFL Week 10
  • Cowboys Spread: -5.5.
  • Packers Spread: +5.5.
  • Over/Under: 42.5

What was expected to be a game between two of the greatest teams in the NFC could end up being disastrous for the Packers on Sunday when they play the Cowboys.

Dallas is coming off its bye week and has a chance to clinch one of the wild card spots with a 6-2 record after they won 29-49 over the Bears in its last game. The return of Dak Prescott as offensive leader has been noticeable in an offense that in the first six weeks had surpassed 24 points only once. This, coupled with one of the best defenses in the circuit, bodes well for the Cowboys.

Meanwhile, Green Bay suffered its fifth consecutive loss, falling 9-15 to the Lions and slipping out of the postseason standings with a 3-6 record. Aaron Rodgers has been far from the MVP of the past two seasons, and against Detroit he threw three interceptions to reach seven on the season, his most since 2016. With no offense and a defense that has allowed more than 20 points in five of the last six games, things aren’t looking good for the Packers.

Prediction: Cowboys Spread.

[Cowboys vs Packers NFL Week 10 full betting preview here]

Arizona Cardinals (+150) vs Los Angeles Rams (-185) / Sunday, November 13 / 4:25 PM E.T.

NFL Week 10
  • Cardinals Spread: +3.0.
  • Rams Spread: -3.0.
  • Over/Under: 43.5

The Cardinals and Rams, the two bottom teams in the NFC West, will close out the day on Sunday with a critical matchup. They have already faced each other this year, with Los Angeles winning 20-12.

Arizona practically buried its aspirations by losing for the second time this season to the division-leading Seahawks, leaving its record at 3-6. The Cardinals have been unable to hold leads this season due to their offensive struggles and after the defense put them up 10-14 early in the third period, they were outscored 21-7 by Seattle’s high-powered offense.

For their part, the Rams aren’t in good shape either and seem to have a very difficult time defending their championship title, falling to a 3-5 record after their 13-16 loss to the Buccaneers. Offense has been the main problem for Los Angeles, as in none of their five losses have they been able to surpass 14 points scored. Their defense hasn’t been as strong, but it’s kept games close while they waited for Matthew Stafford to bounce back, which never happened.

Prediction: Rams Spread.

[Cardinals vs Rams NFL Week 10 full betting preview here]

Los Angeles Chargers (-240) vs San Francisco 49ers (-300) / Sunday, November 13 / 8:20 PM E.T.

NFL Week 10
  • Chargers Spread: +7.0.
  • 49ers Spread: -7.0.
  • Over/Under: 46.5

One of the most interesting games of the day will be played this coming Sunday night when the Chargers and 49ers face off in another edition of Sunday Night Football.

Despite multiple painful injuries, Los Angeles remains second in the AFC West and one of the conference’s wild cards with a 20-17 win over the Falcons to improve their record to 5-3. With six points in the fourth period, all of them on field goals, including a 37-yarder to seal the game with no time on the clock, the Chargers remain in the hunt for the Chiefs.

On the other hand, the 49ers are refreshed after completing their bye week and having a 4-4 record after beating the Rams, 31-14, in their last action on the gridiron. The San Francisco team has been intermittent all year, and against Los Angeles, its defense was finally able to shine again by allowing less than 290 total yards to its opponents for the sixth time.

Prediction: Chargers Spread.

[Chargers vs 49ers NFL Week 10 full betting preview here]

Washington Commanders (+375) vs Philadelphia Eagles (-500) / Monday, November 14 / 8:15 PM E.T.

NFL Week 10
  • Commanders Spread: +10.5.
  • Eagles Spread: -10.5.
  • Over/Under: 44.5.

NFL Week 10 closes next Monday with Monday Night Football between the Commanders and the undefeated Eagles, NFC East division rivals who have already met this year, with Philadelphia winning 24-8.

Washington snapped a streak of three consecutive wins by losing in extremis against the Vikings by a 20-17 score to drop their record to 4-5. The Commanders’ good defense allowed 13 points in the last quarter and with a Greg Joseph field goal, they missed a great opportunity to get a good record. Meanwhile, Taylor Heinicke has enhanced an attack that will have a difficult time against their opponents’ defense.

That defense, which leads the league in fumbles recovered with 18, will be looking to maintain the team’s undefeated record after a 29-17 win over the Texans last Sunday. Philadelphia leads the NFC East with an 8-0 record, as Jalen Hurts continues to be the offensive leader. Moreover, the Eagles have been unstoppable in both the running and passing game.

Prediction: Commanders Spread.

[Commanders vs Eagles NFL Week 10 full betting preview herech]


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