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MLB Best Bets of 2023 Opening Day | Top Plays for the Major Leagues’ Opening Day

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The new, larger base is seen on the field at TD Ballpark Wednesday, Feb. 15, 2023, in Dunedin, Fla. Opening day will feature three of the biggest changes in baseball since 1969: Two infielders will be required to be on either side of second base, base size will increase to 18-inch squares from 15 and a pitch clock will be used. (AP Photo/Brynn Anderson)

Get ready for a thrilling ride as MLB Opening Day 2023 season kicks off next Thursday! With a full slate of games scheduled, there will be plenty of excitement and intriguing matchups to keep you on the edge of your seat.

Without further ado, JefeBet is eager to see how the new rules will impact each game this season. That’s why it’s partnered with DraftKings to bring you a list of the top odds and bets you can make on the MLB Opening Day 2023.

Summary of the MLB Best Bets in Opening Day Held on March 30, 2023

Atlanta Braves vs Washington Nationals

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Looking for a safe bet in spite of the high odds for the upcoming MLB Opening Day 2023? Look no further than the Braves’ Moneyline, paying out at (-245). While it may not be the simplest play, it’s a great addition to any parlay.

But why not take a chance on the spread (-1.5, -140)? The Braves are led by one of the best pitchers in the game, Max Fried, and are up against an offense that could easily end up as one of the worst in the league.

And let’s not forget about the Braves’ potent attack, which has a 41-16 record against the Nationals in their last 57 matchups. Plus, Washington’s starter, Patrick Corbin, has a lifetime ERA of 4.48 against Atlanta, and a 6.02 ERA over his last 62 starts. Don’t miss out on this opportunity to cash in big!

Prediction: Atlanta Braves Spread/Moneyline.

Minnesota Twins vs Kansas City Royals

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Despite being visitors, the Twins must start the MLB season on the right foot against a Royals team with many doubts about their offense.

Pablo López will make his debut with Minnesota against an attack that, beyond Bobby Witt Jr. and Salvador Pérez, generates many doubts when it comes to producing runs. Furthermore, let’s remember that the Venezuelan comes from two great MLB seasons with the Marlins.

On the Royals’ side, the starter will be the experienced Zack Greinke, who hasn’t had very good feelings facing the Twins in his career. Actuallly, in 30 games, 26 as a starter, he has a record of 5-13 with an ERA of 4.55.

It’s worth noting that the Twins have a record of 12-5 in their last 17 matches against Kansas City, and their Moneyline is quite attractive, paying (-140). So, it’s time to bet on the Twins and make some money.

Prediction: Minnesota Twins Moneyline.

Colorado Rockies vs San Diego Padres

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Get ready for an exciting match-up between the Rockies and Padres, as they promise to deliver a thrilling display of skills on the field for the MLB Opening Day 2023.

Led by the powerful duo of Kris Bryant and C.J. Cron, the Rockies boast a strong offense that is sure to put up a good fight against Blake Snell, who has struggled against them in the past. Snell has pitched 46.2 innings against the Rockies, giving up 22 walks and holding an ERA of 4.24.

On the other hand, the Padres have one of the most feared lineups in the league, and they will face Germán Márquez, who has had an ERA above 4.40 in the last two seasons. But Márquez has also struggled against the Padres in the past, with a 4.47 ERA, and 15 home runs allowed in 92.2 innings pitched.

It’s worth noting that four out of the last five games between these teams have ended in Over, and the line for this game is set at 7.5 (-105), so get ready for some high-scoring action!

Prediction: Over.

Pittsburgh Pirates vs Cincinnati Reds

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At the end of the season, neither of these teams should be fighting for anything significant. Nonetheless, someone has to win their head-to-head matchups, and this time the Reds have the edge.

The Cincinnati squad starts at home with a slightly more complete team than their rivals. On the mound, they will have the speedster Hunter Greene, who in his rookie year opened twice against Pittsburgh, leaving an ERA of 0.68 without allowing homers in 13.1 innings.

On the other hand, Mitch Keller, his counterpart, must have nightmares about facing the Reds. After starting 11 games against them, and pitching 49.0 innings, the right-hander has an ERA of 6.80 with 28 walks allowed and eight homers given up.

Undoubtedly, this is a good opportunity for Cincinnati, a team that pays (-145) on the Moneyline, to end their streak of seven consecutive losses against Pittsburgh.

Prediction: Cincinnati Reds Moneyline.

Los Angeles Angels vs Oakland Athletics

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Let’s talk about the opening of the best baseball player in the world: Shohei Ohtani. After winning the MVP award in the World Baseball Classic with Japan, the right-hander will be the one to open the game on Opening Day for the Los Angeles Angels against the Athletics.

Last season, Ohtani came fourth in the American League Cy Young Award voting, and has a lifetime ERA of 2.50 with 69 strikeouts in 57.2 innings against Oakland.

On the other hand, Kyle Muller, from the Braves, will open for the first time against a team that has all its heavy artillery available. The left-hander, who has a lifetime ERA of 5.14, will have to face Mike Trout, Anthony Rendón, Gio Urshela, Hunter Renfroe, and Ohtani himself.

The Angels’ victory, who have won six of their last ten games against Oakland, is paid at a rate of (-210). It might be a bit high, but it’s worth combining. Keep your eyes on this game!

Prediction: Los Angeles Angels Moneyline.


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Written by Henry Roldán

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