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2022 NFL Week 17 Predictions, Odds and Betting Previews

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A general overall interior view of Paycor Stadium during an NFL football game between the Cincinnati Bengals and the Miami Dolphins, Thursday, Sept. 29, 2022, in Cincinnati. (AP Photo/Emilee Chinn)

Week 16 of the 2022 season has gone by, and now we’re heading into NFL Week 17, which tells us that the campaign is entering its final stretch. As we do every week, here at JefeBet, we bring you the best predictions for this new NFL week for all games that will be played throughout the following days.

A total of 16 games will be played between December 29 and January 2, taking into account that the rest days for the teams are over. Without further ado, here are our predictions for this new week of National Football League action.

All odds shown are courtesy of BetMGM.

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Predictions, Odds and Betting Previews for All 2022 NFL Week 17 Games

Dallas Cowboys (-500) vs Tennessee Titans (+360) / Thursday, December 29 / 8:15 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Cowboys Spread: -10.0.
  • Titans Spread: +10.0
  • Over/Under: 40.5

NFL Week 17 will kick off Thursday with a stellar Thursday Night Football between the Cowboys and Titans.

Dallas is coming off a big 34-40 win over the Eagles and still has hopes of winning the NFC East and the National Conference. With a record of 11-4, the Cowboys must win all of their games and hope that Philadelphia loses all of theirs. In their last eight games, Dallas scored at least 27 points and in four of them more than 40.

Meanwhile, (and unbelievably) the Titans could fall out of the postseason after stringing together five consecutive losses. After being defeated at home 19-14 by the Texans, the worst team in the league, Tennessee is tied for the lead in the AFC South with the Jaguars at 7-8. However, as of this week, Jacksonville is winning the head-to-head matchup. These teams will be facing off next week. The Titans’ defense is one of the most solid on the ground, but their offense is a real headache.

Prediction: Titans Spread.

[Cowboys vs Titans NFL Week 17 full betting preview here]

Arizona Cardinals (+155) vs Atlanta Falcons (-190) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Cardinals Spread: +4.0.
  • Falcons Spread: -4.0.
  • Over/Under: 41.

The Cardinals, who have dropped five straight games and are currently in last place in the NFC West with a 4-11 record, are among the season’s biggest letdowns. Arizona’s future is significantly gloomier now that Kyler Murray can no longer serve as the team’s leader due to injury.

After dominating the NFC South for several weeks and becoming the first club eliminated from the NFL’s weakest division, Atlanta’s emotions must be all over the place. The Falcons’ last defeat, a 9-17 defeat to the Ravens, pushed them out of contention with the Buccaneers for first place in the division after they suffered six defeats in their previous seven games. This leaves them with a 5-10 record overall.

Prediction: Falcons to win.

[Cardinals vs Falcons NFL Week 17 full betting preview here]

Chicago Bears (+220) vs Detroit Lions (-275) / Sunday, January 1st / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Bears Spread: +6.0.
  • Lions Spread: -6.0.
  • Over/Under: 52.0.

With a 3-12 record, the team from Chicago has already been eliminated from postseason contention and currently holds the second-to-last spot in the NFL, in addition to the bottom spot in the NFC North and the whole National Conference. The Bears currently hold the second overall pick in the forthcoming draft, so it is unclear how eager they are to try to ruin the fun for their division rivals.

The Lions have won six of their last eight games and are just a half-game behind the Commanders for the final NFC wild card with a 7-8 record. Considering this, it will be crucial for them to win this game, their last at home, before closing the season by visiting the Packers, a team that could also reach that game with a chance of postseason. It has to be said that Detroit has one of the best offenses in the league and its defense has been improving.

Prediction: Over.

[Bears vs Lions NFL Week 17 full betting preview here]

Jacksonville Jaguars (-210) vs Houston Texans (+170) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Jaguars Spread: -4.0.
  • Texans Spread: +4.0.
  • Over/Under: 43.5

Thanks to five wins in their last seven games, the Jaguars have tied the Titans for the lead in the AFC South with a 7-8 record and a 7-2 record. Due to their victory in the head-to-head comparison to the Titans, they are currently in the postseason. The Jacksonville team has a great opportunity to maintain that position and reach the last day of the regular round, precisely against the Titans, with the advantage on their side. Trevor Lawrence’s air strike was the trigger for this great moment.

On the Texans’ side, it is still unclear whether they will make much of an effort in their final two games to secure the top pick in the draft or if they will maintain the strong play of the previous few weeks, during which they battled against the Cowboys and Chiefs and triumphed against the Titans. Meanwhile, the Houston team has the worst record in the league at 2-12-1.

Prediction: Jaguars to win.

[Jaguars vs Texans NFL Week 17 full betting preview here]

Denver Broncos (+550) vs Kansas City Chiefs (-800) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Broncos Spread: +13.5.
  • Chiefs Spread: -13.5.
  • Over/Under: 45.5

The Broncos’ disappointing season has already claimed its first victim after head coach Nathaniel Hackett was fired by the organization. Denver is last in the AFC West with a 4-11 record and is coming off a 14-51 drubbing by the Rams. Hiring Russell Wilson did not pay off at all, and they could even end up among the five worst teams in the league.

Kansas City has already clinched the postseason and the division, but they are still in contention with the Bills for the best record in the American Conference. Both are even at 12-3, with the Bengals on their heels. Now more than ever they need the offense led by Patrick Mahomes to show why it is considered the best in the league.

Prediction: Chiefs spread.

[Broncos vs Chiefs NFL Week 17 full betting preview here]

Miami Dolphins (+120) vs New England Patriots (-145) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Dolphins Spread: +2.5.
  • Patriots Spread: -2.5.
  • Over/Under: 42.0.

The Dolphins and Patriots will put their season on the line this Sunday when they meet for the second time this campaign.

Miami occupies the final wild card in the AFC with a record of 8-7, but New England is just one game back. The Dolphins already beat the Patriots in the first week of action, but the Patriots are not in good shape after losing their last four games and having their QB, Tua Tagovailoa, back in concussion protocol.

For their part, the Patriots are also not coming into the game in their best shape after losing four of their last five games, including the last one to the Bengals 22-18. The New England team has a 7-8 record and if they don’t get a win against Miami, they will be eliminated from the fight for the postseason. Will their good defense be able to stop Miami’s powerful offense?

Prediction: Dolphins to win.

[Dolphins vs Patriots NFL Week 17 full betting preview here]

Indianapolis Colts (+180) vs New York Giants (-225) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Colts Spread: +5.0.
  • Giants Spread: -5.0.
  • Over/Under: 39.5.

The final two games of the regular season will be only a task to complete for Indianapolis, who have nothing to look forward to this season. They have now dropped five straight games and are third in the AFC South with a 4-10-1 record after their 20-3 loss to the Chargers. Their defense is the only redeemable feature, since the offense is a complete fiasco.

Before finishing the season in Philadelphia, New York knows they must defeat the struggling Colts at home. The Giants, who now have an 8-6-1 record following their 24-27 loss to the Vikings, could potentially secure the second wild-card berth in the AFC with a victory on Sunday.

Prediction: Under.

[Colts vs Giants NFL Week 17 full betting preview here]

New Orleans Saints (+240) vs Philadelphia Eagles (-300) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Saints Spread: +7.0.
  • Eagles Spread: -7.0.
  • Over/Under: 44.0.

While the Saints come into the game looking for a miracle, the Eagles are looking to close out once and for all with the best record in the NFC.

Members of the NFC South, the New Orleans team are still hoping to catch the Buccaneers for the division lead, but they will not have an easy fight in Philadelphia. The Saints are coming off a 17-10 loss to the Browns and with a 6-9 record remain one game behind Tampa Bay. The problem is that they lost both games against them and in order to beat them, they must win the last two and have Tom Brady and company lose theirs.

The Eagles were unable to seal the division last weekend against the Cowboys, but could do so this Sunday in front of their home fans. With a win, Philadelphia, which has a 13-2 record, would also secure the best record in the National Conference to rest the first week of the postseason. Justin Fields is also expected to be back at QB after his absence against Dallas due to shoulder discomfort.

Prediction: Over.

[Saints vs Eagles NFL Week 17 full betting preview here]

Carolina Panthers (+135) vs Tampa Bay Buccaneers (-160) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Panthers Spread: +3.0.
  • Buccaneers Spread: -3.0
  • Over/Under: 39.5.

The NFC South could also be defined this Sunday with the crucial matchup between the Panthers and Buccaneers.

With three wins in its last four games, including one last weekend by 23-37 over the Lions, Carolina has a 6-9 record and is just one game behind the Buccaneers at the top of the division. The Panthers have already beaten Tampa Bay in one game this year and if they win this Sunday, they would practically take the division from Tampa Bay. What is the team’s secret? A defense that hasn’t let up more than 24 points in six straight matchups.

Tampa Bay, on the other hand, still has a chance, despite its 7-8 record, to define the division and reach the postseason. The Buccaneers have performed much below expectations, particularly on offense, where they have only once all season scored more than 23 points. In this way, they will require their Top 10-defense even more to help the, reach the coveted postseason spot.

Prediction: Under.

[Panthers vs Buccaneers NFL Week 17 full betting preview here]

Cleveland Browns (+115) vs Washington Commanders (-135) / Sunday, January 1 / 1:00 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Browns Spread: +2.0.
  • Commanders Spread: -2.0.
  • Over/Under: 40.5

The Browns were unable to win a do-or-die game last week at home against the Saints and said goodbye to the postseason. Cleveland lost its second game in the last three weeks, this time 17-10, to drop to a 6-9 record and miss out on at least the third wild card in the AFC. They expected the return of Deshaun Watson to be the solution, but it was more of a problem.

The fact that Washington will play at home against teams who may not be aiming for anything in these final two weeks is their lone advantage. This week’s game against Cleveland is an example of that. Meanwhile, the following Sunday, they will face the Cowboys, who are awaiting other teams’ results. With a 7-7-1 record, the Commanders are in the NFC’s final wild card spot, but they only hold a one-half game advantage over the Seahawks, Lions, and Packers.

Prediction: Under.

[Browns vs Commanders NFL Week 17 full betting preview here]

San Francisco 49ers (-250) vs Las Vegas Raiders(+200) / Sunday, Jan. 1 / 4:05 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • 49ers Spread: -6.0.
  • Spread Raiders: +6.0.
  • Over/Under: 44.5.

The Eagles’ loss to the Cowboys gave the 49ers hope, at least for one more week, to dream of the best record in the NFC. San Francisco has now won eight consecutive games and with a record of 11-4, they have already clinched the NFC West championship. In light of the team’s history of injuries, the question is if Kyle Shanahan will take care of key players or if they will continue to strive for the best record.

Although they have not yet been eliminated in Las Vegas, they are relying on a miracle to keep their season alive. Last week, the Raiders lost to the Steelers 10-13 after blowing a lead once more, dropping their record to 6-9. Remember that during this season, this squad blew three leads of at least 17 points.

Prediction: Under.

[49ers vs Raiders NFL Week 17 full betting preview here]

New York Jets (-130) vs Seattle Seahawks (+110) / Sunday, January 1 / 4:05 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Jets Spread: -2.0.
  • Seahawks Spread: +2.0.
  • Over/Under: 42.5

Another do-or-die duel will take place on Sunday afternoon when the Jets and Seahawks meet.

New York comes into the game with a 7-8 record after losing four consecutive games and six of its last eight. The Jets have had a lot of problems on offense and this has cost them dearly despite their great defense. With a win, they’d have a chance to reach their direct duel against the Dolphins in the last week, while with a loss they’d say goodbye to the postseason.

In Seattle’s case, a loss could also send them home if the Commanders win their game. The Seahawks have lost three in a row and five of their last six games, something that has complicated their postseason aspirations despite leading the NFC West for a few weeks. Now, with a 7-8 record, they must win against the Jets and Rams and hope for a Washington loss to get into the third wild card of the National Conference.

Prediction: Seahawks to win.

[Jets vs Seahawks NFL Week 17 full betting preview here]

Minnesota Vikings (+145) vs Green Bay Packers (-175) / Sunday, January 1 / 4:25 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Vikings Spread: +3.5.
  • Packers Spread: -3.5.
  • Over/Under: 48.5

Despite having already qualified for the postseason, the Vikings still have a chance to catch the Eagles with the best record in the NFC and give their arch-rivals in the division, the Packers, a run for their money. Minnesota already beat them this year, and now they could eliminate them at Lambeau Field, which is significant encouragement for a team that comes in with a 12-3 record as champions of the NFC North.

In order for the Packers to sneak into the third NFC wild card, they must win their next two games and tie a bunch of other outcomes. They have at least responded thus far with two straight victories, the most recent being 26-20 versus the Dolphins, giving them a 7-8 record. The rise of Aaron Rodgers as the offensive team’s quarterback has been crucial for them.

Prediction: Over.

[Vikings vs Packers NFL Week 17 full betting preview here]

Los Angeles Rams (+240) vs Los Angeles Chargers (-300) / Sunday, January 1 / 4:25 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Rams Spread: +6.5.
  • Chargers Spread: -6.5.
  • Over/Under: 41.0.

With two wins in their last three games, the Rams seem to want to make up for a campaign that will go down in history as the worst regular round start for a defending champion. Los Angeles is third in the NFC West with a 5-10 record and is coming off a 14-51 win over the Broncos with another good game from Baker Mayfield.

Their crosstown neighbors, the Chargers, secured their postseason berth Monday night with their 20-3 win over the Colts. That was the third consecutive win and fourth in the last five games for the team that occupies the second wild card spot in the AFC with a 9-6 record.

Prediction: Over.

[Rams vs Chargers NFL Week 17 full betting preview here]

Pittsburgh Steelers (+135) vs Baltimore Ravens (-160) / Sunday, January 1 / 8:20 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Steelers Spread: +3.0.
  • Ravens Spread: -3.0.
  • Over/Under: 36.0.

With five wins in their last seven games, the Steelers still have a chance to sneak into the third wild card in the AFC. However, they must now get past their division arch rival, the Ravens. Despite being one of the teams with the most offensive deficiencies, Pittsburgh has found the formula to win and come into this game with a 7-8 record, one game behind the Dolphins in the postseason standings.

The Ravens have already clinched a playoff berth, but need to win on Sunday Night Football this Sunday to still have a shot at the top spot in the AFC North. Baltimore lost the top spot to the Bengals but, with a 10-5 record and having to visit Cincinnati next week, they still have a chance to retake it. That said, it all depends on whether Lamar Jackson is ready to return to action.

Prediction: Under.

[Steelers vs Ravens NFL Week 17 full betting preview here]

Buffalo Bills (-120) vs Cincinnati Bengals (+100) / Monday, January 2 / 8:15 PM E.T.

NFL Week 17 Predictions Picks Betting Odds
  • Bills Spread: -1.5.
  • Bengals Spread: +1.5.
  • Over/Under: 49.5.

The Bills will face the Bengals on Monday Night Football, the NFL’s most interesting Week 17 clash. Despite already having made it to the postseason, both teams are contending for the top record in the American Conference.

Buffalo comes into the matchup with six consecutive wins and the AFC East lead at 12-3. In fact, the Bills are, for now, number one in the conference by winning the head-to-head matchup with the Chiefs. However, this is something that could change if they don’t win in Cincinnati.

The Bengals are the hottest team in the league with seven straight wins and an 11-4 record. Thanks to their good form, they have already taken the AFC North lead from the Ravens and could do the same in the Conference with the Bills. Moreover, Cincinnati already beat the Chiefs, so with a win they would have the advantage in any tie with Kansas City and Buffalo.

Prediction: Over.

[Bills vs Bengals NFL Week 17 full betting preview here]


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