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Buffalo Bills vs Kansas City Chiefs Predictions, Picks, Odds, and Betting Preview | NFL Week 6 2022

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Buffalo Bills quarterback Josh Allen (17) is tackled by Kansas City Chiefs defensive tackle Jarran Reed (90) during the first half of an NFL divisional round playoff football game, Sunday, Jan. 23, 2022, in Kansas City, Mo. (AP Photo/Colin E. Braley)

Among the most spectacular games in Week 6 of professional footballwe have the Bills vs Chiefs game, which featurestwo of the favorites in Las Vegas to win the Super Bowl, and who last season dazzled us with a spectacular matchup in the AFC Divisional Game.

Buffalo is coming off a 3-38 drubbing of the Pittsburgh Steelers to climb to the top of the AFC East, while Kansas City remains atop the AFC West after winning a big game Monday night over the Las Vegas Raiders, 29-30.

Without further ado, at JefeBet we bring you the best preview of Buffalo Bills vs Kansas City Chiefs, the two best teams in the American Conference today.

Predictions and Betting Preview for the Buffalo Bills vs Kansas City Chiefs NFL Week 6 Game on October 16, 2022

Bills vs Chiefs Predictions Picks Betting Odds
  • Where: GEHA Field at Arrowhead Stadium – Kansas City, Missouri.
  • When: Sunday, October 16, 2022, 4:25 PM E.T.

Odds courtesy of BetMGM.

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Betting on the Buffalo Bills

Bills vs Chiefs Predictions Picks Betting Odds
  • Regular Season record: 4-1
  • BetMGM Spread: -2.5.
  • Moneyline: (-145).
  • Over/Under: 54.

Under the leadership of Josh Allen, the Bills remain as the main favorites to win the NFL championship this season, and they have done enough to make it happen.

Thanks to the 1,651 air yards and 330.2 yards per game that Allen averages, which have him as the leader in those categories, Buffalo ranks first overall in total yards (2,202) in the league. Moreover, they are co-leaders in net yards per pass with 7.6. Furthermore, their 152 points so far in 2022 rank second only to the Chiefs, and no one averages more yards per play than they do at 6.7.

The most fearsome thing about the Bills, though, is that their defense is equal to or better than the offense. They, along with the 49ers, are the teams that have allowed the fewest points to their opponents with 61, are co-leaders in fumbles recovered (11) and interceptions (8), in addition to being second in lowest average yards conceded per play with 4.4. The question is if they’ll be able to keep those averages intact when facing Patrick Mahomes.

Betting on the Kansas City Chiefs

Bills vs Chiefs Predictions Picks Betting Odds
  • Regular Season record: 4-1
  • BetMGM Spread: +2.5.
  • Moneyline: (+120).
  • Over/Under: 54.

The Chiefs may not be as good on defense as the Bills, but their offense is on par and even surpasses Buffalo’s in some categories within the league.

Under Mahomes, who is on the ballot to be considered the best QB in the league along with Allen, no one has scored more points this season than Kansas City’s 159. Moreover, they are the offense with the most first downs with 124, and the 15 aerial TDs scored by the quarterback put him as the leader in the category, surpassing the 14 thrown by the Bills’ quarterback.

As mentioned, the team’s weak link, and one that could take its toll against a roster as complete as Buffalo’s, is its defense. The 125 points conceded this year and 1,278 air yards allowed are the ninth most in the league, while they total just four fumbles recovered, the third-lowest figure, and the 12 air TDs scored against them are the biggest figure.

However, it’s not all negative as they allow the seventh lowest average yards per carry on the ground with 4.1.

JefeBet Prediction

Dots, dots and more dots. Just as they scored 78 points in last season’s Divisional Game, this Sunday afternoon’s showdown between Allen and Mahomes promises to be a two-sided scoring fest.

Yes, Buffalo’s defense is one of the best in the league, but this time they face a Chiefs team that scored 44 points on Arizona and 41 points on the Buccaneers, both more than decent defenses. On the other hand, Allen will feast on Kansas City’s defense, so whoever gets weary of scoring the most will win.

Prediction: Over (BUF 34 – KC 31).


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Written by Henry Roldán

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