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Los Angeles Chargers vs San Francisco 49ers Predictions, Picks, Odds, and Betting Preview | NFL Week 10 2022

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San Francisco 49ers running back Wayne Gallman is tackled during the second half of a preseason NFL football game against the Los Angeles Chargers Sunday, Aug. 22, 2021, in Inglewood, Calif. (AP Photo/Ashley Landis)

Week 10 of NFL action will provide us with a great Sunday Night Football matchup as the Chargers vs. 49ers look to solidify their paths to the postseason.

Los Angeles is coming off a hard-fought 20-17 win over the Falcons on the road, while San Francisco enjoyed their bye week in style after beating the Rams 31-14 in their last game.

Without further ado, at JefeBet we bring you the best preview of this exciting matchup between Los Angeles Chargers vs San Francisco 49ers.

Predictions and Betting Preview for the Los Angeles Chargers vs San Francisco 49ers NFL Week 10 Game on November 13, 2022

Chargers vs 49ers Predictions Picks Betting Odds
  • Where: Levi’s Stadium – Santa Clara, California.
  • When: Sunday, November 13, 2022, 8:20 PM E.T.

Odds provided by BetMGM.

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Betting on the Los Angeles Chargers

Chargers vs 49ers Predictions Picks Betting Odds
  • Season record: 5-3.
  • BetMGM Spread: +7.0
  • Moneyline: (+240)
  • Over/Under: 45.5

Despite the many injuries that have plagued the Chargers, the team has found ways to win and is currently in a good position in the AFC West.

Thanks to a six-point comeback in the final period on the strength of two field goals, Los Angeles earned a win over the Falcons that keeps them just one game behind the Chiefs for the division lead and as the third wild card in the American Conference.

On the offensive side, Justin Herbert has had to carry the offense once again, considering that the Chargers’ ground game is one of the worst in the circuit, while the defense is the fourth highest in yards per play average at 5.9. In this way, it’s not surprising that four of his five wins have happened by five or fewer points.

Betting on the San Francisco 49ers

Chargers vs 49ers Predictions Picks Betting Odds
  • Season record: 4-4.
  • BetMGM Spread: -7.0
  • Moneyline: (-300).
  • Over/Under: 45.5

San Francisco is another team that has looked like a future champion some weeks and absolutely underwhelming in others this season.

With one of the best defenses in the league, the 49ers have an even record after snapping a two-game losing streak to the Rams. They allowed only 223 total yards to the reigning champions in that game; moreover, they have the lowest yards per carry average in the league at 3.4, and they are third in yards per play average at 3.8.

On offense, the 49ers haven’t fared much better, and the explanation for their losses is that in three of those four games, they lost the ball three times and turned it over a couple of times. San Francisco is fourth in average net yards per pass with 7.1 and is sixth in average yards per play with 5.9.

JefeBet Prediction

Although San Francisco’s defense is one of the best in the league, Los Angeles has found a way to score in most of its games and has reached at least 20 points in six of its eight games.

The 49ers offense has also had a string of high-scoring games, including five games of 24 points or more, which could happen again against a Chargers defense that has been inconsistent in its interventions. In addition, four of the last five games between the two have resulted in a win.

Prediction: Over (LA 20 – SF 27).


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