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New Orleans Saints vs San Francisco 49ers Predictions, Picks, Odds, and Betting Preview | NFL Week 12 2022

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New Orleans Saints wide receiver Jarvis Landry (5) celebrates after scoring a touchdown against the Los Angeles Rams in the second half of an NFL football game in New Orleans, Sunday, Nov. 20, 2022. (AP Photo/Gerald Herbert)

Week 12 of the 2022 NFL season will feature a clash of National Conference teams on Sunday, Nov. 27: Saints vs 49ers. The matchup certainly has a particular appeal just by virtue of being an NFC matchup, but what makes it even more intriguing is maybe the fact that the 49ers are now having their greatest season while the Saints have not been able to stabilize and have continued their ups and downs.

The New Orleans team is in the NFC South and to some extent that’s a plus, being the worst division of the season as all the teams have been inconsistent. With one more win, they would catch up with the current leaders, the Tampa Bay Buccaneers. On the other hand, San Francisco wants to confirm its position as the best in the NFC West and continue its winning streak.

Everything you need to know before this New Orleans Saints vs San Francisco 49ers game as well as the rest of the NFL Week 12 matchups can be found in JefeBet’s previews.

Predictions and Betting Preview for the New Orleans Saints vs San Francisco 49ers NFL Week 12 Game on November 27, 2022

Saints vs 49ers Predictions Picks Betting Odds
  • Where: Levi’s Stadium, Santa Clara, Calif.
  • When: Sunday, November 27, 2022, 4:25 PM E.T.

Betting on the New Orleans Saints

Saints vs 49ers Predictions Picks Betting Odds
  • Regular season record: 4-7
  • DraftKings Spread: +9.5
  • BetMGM Moneyline: +333
  • Over/Under: 43

After losing two consecutive games, 27-13 to Baltimore and 20-10 to the Pittsburgh Steelers, the New Orleans Saints picked up an important win over the Los Angeles Rams 27-20. This was their fourth win of the season and although it could be considered a low win total, in their division the teams with the most wins have just one more.

In each of their wins, New Orleans has scored more than 20 points. They have the second highest points for record in the NFC South with 249, and also the second highest points against with 267, which highlights their inconsistencies.

Betting on the San Francisco 49ers

Saints vs 49ers Predictions Picks Betting Odds
  • Regular season record: 6-4
  • DraftKings Spread: -9.5
  • BetMGM Moneyline: -450
  • Over/Under: 43

The San Francisco 49ers are coming off a 38-10 win over the Arizona Cardinals on Monday Night Football in Mexico City, completing their third consecutive victory. The Californian franchise is celebrating right now, as this is the first time it has managed to win more than two in a row this season.

They have taken the lead in the NFC West with their 6-4 record, along with the Seattle Seahawks, the two teams with the most wins in that region. The highlight of the team is their defense, and so far they have only allowed 173 points.

JefeBet Prediction

The 49ers offense led by Jimmy Garoppolo is also doing well and in four of the last five games they have been able to score 20 points or more regardless of the score. This is their best moment of the season and they will be looking to capitalize on it to continue dreaming of the divisional title.

Prediction: San Francisco 49ers win and Over.

Odds shown are courtesy of BetMGM and DraftKings. Check out our reviews!


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Written by Mayra Madrigal

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