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Pittsburgh Steelers vs Buffalo Bills Predictions, Picks, Odds, and Betting Preview | NFL Week 5 2022

FILE - The field is prepared at Highmark Stadium before an NFL football game between the Buffalo Bills and the Carolina Panthers, Dec. 19, 2021, in Orchard Park, N.Y. The Bills moved closer to landing $200 million in NFL funding to help finance their bid to build a new stadium, a person with direct knowledge of the situation told The Associated Press on Friday, March 25, 2022. (AP Photo/Joshua Bessex, File)

We’re well into the 2022 NFL regular season, and teams have had plenty of time to get up to speed and compete at their best. Considering this, there’s no excuse for poor performance any longer. This Week 5, the Steelers vs. Bills matchup pits two teams with very different goals from now until the end of the season.

Since the start of the preseason, you’ve been enjoying all the NFL action at JefeBet, and this week will be no exception. We’ll keep bringing you the greatest picks and games analyses, including, in this article, all Steelers vs Bills predictions and betting odds.

Predictions and Betting Preview for the Pittsburgh Steelers vs Buffalo Bills NFL Week 5 Game on October 9 2022

Steelers vs Bills Predictions Picks Betting Odds
  • Where: Highmark Stadium, Orchard Park, New York.
  • When: Sunday, October 9, 2022, 1:00 PM E.T.

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Betting on the Pittsburgh Steelers

Steelers vs Bills Predictions Picks Betting Odds
  • Season record: 1-3
  • BetMGM Spread: +14
  • BetMGM Moneyline: +600
  • Over/Under: 47.5 Points

The Pittsburgh Steelers enter Week 5 of the NFL regular season in last place in the AFC North division. After defeating the Bengals in Week 1, the team has lost three consecutive games with the last of them before the New York Jets. This was an agonizing game, as they blew a ten-point lead in the fourth quarter and lost 24-20.

The main news within the Steelers this week has been that rookie Kenny Pickett will replace Mitch Trubisky at the quarterback position after an outstanding performance in the second half of that game against the Jets, scoring two touchdowns on the ground (although he also had three passes intercepted.)

Betting on the Buffalo Bills

Steelers vs Bills Predictions Picks Betting Odds
  • Season record: 3-1
  • Unibet Spread: -14
  • Unibet Moneyline: -835
  • Over/Under: 47.5 Points

The Bills, leading contenders to win the Super Bowl this season and current second place finishers in the AFC East division, proved that a stumble is not a fall by bouncing back from their Week 3 loss to the Dolphins with a 23-20 win in Week 4 against a great team such as the Baltimore Ravens: a win that certainly serves to reinforce the team’s favorite status.

That matchup against the Ravens tested the Bills’ will, as they went into the half-time break with a 10-point disadvantage and ended up winning with a field goal on the last play of the game despite having just 21:50 minutes of possession. This proved Buffalo’s ability to overcome adversity in games in which it’s not widely dominant.

JefeBet Prediction

The caliber difference between the two teams is stark, and this is why that the bookmakers, and us too, are significantly inclined in favor of Buffalo in this game.

The Bills have everything they need to beat the Steelers by a landslide. They will be playing at home, where they won their most convincing victory of the season (41-7 against the Titans), and have one of the best offenses in the league, with the third-best average of total yards per game (422.3) and the fifth-best average of points per game (28.5).

Buffalo not only excels on offensively, but also on defense: they have allowed only 257 total yards a game, the best average in the league, and the second-fewest points conceded on average at 14.5.

This, coupled with the fact that the Steelers have the second-fewest total yards per game at just 290.5, and that Pickett is still getting used to the team, the Bills will surely put up a win without breaking a sweat.

Prediction: Buffalo Bills Spread (PIT 13 – BUF 33)

Betting odds courtesy of BetMGM and Unibetdon’t miss out on our reviews!


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Written by Hiram Moreno

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