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Indianapolis Colts vs Buffalo Bills Predictions, Picks, Odds, and Betting Preview | NFL Preseason Week 1 2022

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offensive lineman (71) Ryan Bates of the Buffalo Bills blocks against the Indianapolis Colts in an NFL football game, Sunday, Nov. 21, 2021, in Orchard Park, NY. The Colts defeated the Bills 41-15. (AP Photo/Jeff Lewis)

The NFL preseason begins very shortly, and one of the games scheduled for Week 1 of the preseason will feature the Colts vs Bills:a clash between two franchises that will surely be fighting at the top of their division as the 2022 regular season progresses.

At JefeBet, we are getting ready for the return to action on the gridiron right now, and that’s why we bring you the analysis of both teams, the predictions for the match and the odds for the game, as well as other games in this preseason, which will serve as preparation for the 17 weeks of the regular season.

Predictions and Betting Preview for the Indianapolis Colts vs Buffalo Bills NFL Preseason Week 1 Game on August 13, 2022

Colts vs Bills Predictions Picks Betting Odds
  • Where: Highmark Stadium, Orchard Park, New York City
  • When: Saturday, August 13, 4:00 PM ET

Betting on the Indianapolis Colts

Colts vs Bills Predictions Picks Betting Odds
  • Record: 0-0-0
  • Spread: +3.5
  • Moneyline: +170
  • Over/Under: 34

The Colts will hope to have as good a campaign in 2022 as they had in 2021, although this time they will try to make it to a postseason berth.They fell short of qualifying as a wild card by just one tie last season.

This preseason game will also serve to begin to define who will be the starting quarterback in 2022. Will veteran Matt Ryan take over the position? Or will newcomer Nick Foles step up and command the offensive strings for the rest of the season? Both will have the desire, and they should start earning their places right away.

Betting on the Buffalo Bills

Colts vs Bills Predictions Picks Betting Odds
  • Record: 0-0-0
  • Spread: -3.5
  • Moneyline: -200
  • Over/Under: 34

The Buffalo Bills are considered by fans and pundits alike as one of the teams to beat, not only in the North Division, but throughout the American Conference,and the franchise will be hoping this is the year they return to a Super Bowl since 1993 –and will hope not to lose again in this instance if that is the case.

The team had quite a hectic preseason, but it all paid off by securing the re-signing of Stefon Diggs and bringing in a high-quality defensive player like Von Miller, so expectations around the Bills are quite high. Will they be able to handle the pressure? Only time will tell.

JefeBet Prediction

Not having a defined quarterback yet will make this game serve as an experiment for the Colts. Whereas the Bills are already a well-composed team that is looking to get ready for the regular season, so we will trust them to get the win.

Prediction: Buffalo Bills.


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Written by Hiram Moreno

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