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MLS Matchday 21 Predictions, Picks, and Betting Odds | June 24 2023

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Foto: Cortesía Twitter @

The MLS Matchday 21 will take place on Saturday with 14 exciting matchups. And we’re all eagerly anticipating the arrival of Lionel Messi to North American shores.

If you’re looking to place bets on any of these games, we’ve got you covered with the best predictions and plenty of information. Plus, don’t forget that JefeBet has a great bonus if you choose to go with Codere as your odds provider for this thrilling MLS matchday 21.






Predictions, Odds, and Betting Preview for MLS Matchday 21 on June 24 2023

San Jose Earthquakes (+125) vs St Louis City (+205) | Saturday, June 24 | 10:30 PM ET

MLS Matchday 21 Predictions Picks Betting Odds
Photo: Courtesy Twitter @stlCITYsc
  • San Jose Earthquakes‘ Asian Handicap: -1
  • St Louis City FC’s Asian Handicap: : +1
  • Over/Under: 3.5

These two teams have faced each other only once before, with the away team winning in a decisive 3-0 victory. This match took place on March 18th during the fourth matchday of the domestic tournament.

The home team is the second-best host of the tournament and comes with an unbeaten record of nine matches without a loss on their own field, with 13 goals scored and only five conceded. All this is the result of six victories and three draws.

They will face the second team in the Western Conference, who lost the conference lead after losing three of their last four matches. Nevertheless, St. Louis City is the team with the most goals scored in the West (35) and the third-best team in that category in the overall rankings.

There are more than enough reasons to expect a match full of excitement. If you also think this match will cover Over (3.5), Codere offers odds of (+160), which means you can win $160 for every $100 you bet.

Prediction: Over (SJE 2-3 SLC)

DC United (+155) vs FC Cincinnati ( +165) | Saturday, June 24 | 7:30 PM ET

MLS Matchday 21 Predictions Picks Betting Odds
Photo courtesy of @fccincinnati on Twitter
  • DC United’s Asian Handicap : -1
  • FC Cincinnati’s Asian Handicap: +1
  • Over/Under: 2.5

The best team in the league will be visiting DC United’s home field for this MLS Matchday 21. The first and ninth place teams in the Eastern Conference will face each other at Audi Field with completely different realities.

DC United has had two losses in a row, while the visiting team has won four out of their last five games. In addition, the Over (2.5) has been covered in three of their last four direct matches, and both teams have scored in those games.

The most noteworthy fact is that both teams have scored at least one goal in their last five games. Codere offers a line of (-176) for Both Teams Score: Yes. Betting $175 could yield a $100 payout.

Prediction: FC Cincinnati’s Moneyline and Both Teams Score: Yes (DCU 1-3 CIN)

Columbus Crew (110) vs Nashville SC (+275) | Saturday, June 24 | 7:30 PM ET

MLS Matchday 21 Predictions Picks Betting Odds
Photo courtesy Twitter @NashvilleSC.
  • Columbus Crew’s Asian Handicap: -1
  • Nashville SC’s Asian Handicap: +1
  • Over/Under: 2.5

Two Eastern Conference contenders will face off at Lower.com Field in what promises to be an exciting match-up in this MLS Matchday 21. Both teams have won three of their last five games and are among the highest-scoring clubs in the league.

Playing at home, The Black and Gold have won three straight games and scored nine goals in the process. However, it’s worth noting that five of the last six meetings between Columbus Crew and Nashville SC have had fewer than three goals scored.

If you agree with us, you can go to Codere and choose to cover the Under (2.5), which has odds of (+105) that will earn you up to $105 for every $100 bet.

Prediction: Tie and Under (COL 1-1 NAS)

Philadelphia Union (-176) vs Inter Miami (+410) | Saturday, June 24 | 7:30 PM ET

MLS Matchday 21 Predictions Picks Betting Odds
Photo courtesy Twitter @InterMiamiCF.
  • Philadelphia Union’s Asian Handicap: -2
  • Inter Miami’s Asian Handicap: +2
  • Over/Under: 3.5

This is going to be one of the most interesting challenges in the Eastern Conference. The home team is currently in fourth place and their competitor is dead last, with 12 losses in 17 games played. Inter knows they have no other option than to start winning, especially while they wait for Messi to join them.

As if that’s not enough, the visiting team has only scored 16 goals, the third-worst record in the entire league. To make matters worse, the Philadelphia Union has won three straight games at home, scoring three goals in two of them.

In five of the host’s past six matches, the net was shaken at least three times, and the same happened in two of their rival’s three most recent games. If you want to bet on the Over (3.5), Codere offers you a (+140) odds which means you can win $140 for every $100 you risk.

Prediction: Philadelphia Union’s Moneyline and Over (PHI 3-1 INT)

Other MLS Matchday 21 Games to Bet On

MLS Matchday 21 Predictions Picks Betting Odds
Photo: Courtesy of @ATLUTD on Twitter

New England Revolution (-154) vs Toronto FC (+410) | Saturday, June 24, 7:30 PM ET

  • Prediction: Moneyline of New England Revolution and Under (NER 2-0 TOR)

Charlotte FC (+100) vs CF Montreal (+260) | Saturday, June 24 7:30 PM ET

  • Prediction: Moneyline of CF Montreal and Over (CHA 1-2 MON)

New York Red Bulls (+100) vs Atlanta United (+270) | Saturday, June 24 7:30 PM ET

  • Prediction: Both Teams Score: No (NYR 0-2 ATL)

Sporting KC (-134) vs Chicago Fire (+340) | Saturday, June 24 8:30 PM ET

  • Prediction: Over (SKC 3-1 CHI)

Austin FC (-106) vs Houston Dynamo (+270) | Saturday, June 24 8:30 PM ET

  • Prediction: Both Teams Score: Yes (AUS 2-1 HOU)

Real Salt Lake (+145) vs Minnesota United (+175) | Saturday, June 24 9:30 PM ET

  • Prediction: Draw and Under (RSL 1-1 MIN)

Colorado Rapids (+125) vs LA Galaxy (+220) | Saturday, June 24 9:30 PM ET

  • Prediction: Moneyline LA Galaxy and Under (COL 0-1 LAG)

LAFC (-200) vs Vancouver Whitecaps (+550) | Saturday, June 24 10:30 PM ET

  • Prediction: Under (LAFC 2-0 VAN)

Seattle Sounders (+105) vs Orlando City (+250) | Saturday, June 24 10:30 PM ET

  • Prediction: Draw and Under (SEA 1-1 ORL)

Portland Timbers (-106) vs New York City FC (+290) | Saturday, June 24 10:30 PM ET

  • Prediction: Over (POR 3-1 NYC)

Click here to bet on any of these matches.


Bet on the above prediction or the one of your choice, and get a free instant bonus by clicking on the banner below this text.

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