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Napoli vs Ajax Predictions, Picks, and Betting Odds for Champions League Matchday 4 | October 12 2022

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Ajax's Mohammed Kudus, right, challenges Napoli's Mathias Olivera during the Champions League group A soccer match between Ajax and Napoli at the Johan Cruyff ArenA in Amsterdam, Netherlands, Tuesday, Oct. 4, 2022. (AP Photo/Peter Dejong)

Europe’s top club competition is the Champions League, and this week is Matchday 4 of the group stage, which in many cases could be decisive. One of the highlights of this week will be Napoli vs Ajax, a long-awaited rematch.

This is a duel that corresponds to Group A (in which we also have Liverpool and Rangers). Many people are looking forward to this match because, in the previous week of European soccer action, the Italian team humiliated the Dutch at home by a score of 1-6.

At JefeBet we tell you how both teams stand heading into this Napoli vs Ajax match, and we include our predictions and available betting odds.

Predictions, Odds, and Betting Preview for the Napoli vs Ajax Champions League Matchday 4 Game on October 12, 2022

Napoli vs Ajax Predictions Odds Betting Preview October 12, 2022
  • Where: Stadio Diego Armando Maradona (former San Paolo) – Naples, Italy.
  • When: Wednesday, October 12, 2022 at 12:45 PM E.T.
  • Moneyline: Napoli (-175) / Tie (+380) / Ajax (+425).
  • Asian Handicap: Napoli (-0.75, -155), Ajax (+0.75, +110).
  • Over/Under (2.5): Over (-210) / Under (+165).
  • Both teams score: Yes (-185) / No (+145).

All odds shown are courtesy of DraftKings

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Napoli Preview

Napoli vs Ajax Predictions Odds Betting Preview October 12, 2022

This team has had a dream start to the season. Napoli leads Serie A with 23 points and a five-game winning streak. Additionally, it’s also at the top of Group A in the Champions League, as it has won all of its matches so far, which places it in the exclusive club of teams with an ideal score, a privilege currently held by only five participants, some of whom are heavyweights like Real Madrid, Bayern Munich, or Manchester City.

Among those 9 points, the last 3 were historic, as they thrashed last Wednesday’s opponents in Amsterdam by an incredible 6-1 scoreline. Will they be able to replicate this feat at home, or will the Dutch team’s sporting embarrassment play a significant role at the Stadio Diego Armando Maradona?

Luciano Spalletti’s Napoli will be able to count on the return of Victor Osimhen for this Napoli vs Ajax, as the Nigerian striker, who has been out since September 7, has already been training with the team.

Probable lineup (4-3-3): Alex Meret; Giovanni Di Lorenzo, Amir Rrahmani, Kim Min-jae and Mathías Olivera; André Zambo Anguissa, Stanislav Lobotka and Piotr Zieliński; Hirving Lozano, Giacomo Raspadori and Jvicha Kvaratsjelia.

Ajax Preview

Napoli vs Ajax Predictions Odds Betting Preview October 12, 2022

Ajax has only three points so far, and none in the last two games. Admittedly, Group A is perhaps one of the most complex in this Champions League, but no one expected such a performance against Napoli last week.

They are currently second in their league, one point behind AZ, and if they want to keep their chances of qualifying for the second round of the Champions League, they need at least a point in Naples. Ajax coach Alfred Schereuder may be able to have Mexican central defender Jorge Sanchez, one of the club’s most popular players, in its starting roster, but not Duan Tadi, who was sent off in the previous game.

Probable lineup (4-2-3-1): Remko Pasveer; Devyne Rensch, Jurriën Timber, Jorge Sánchez and Daley Blind; Edson Álvarez, Calvin Bassey; Kenneth Taylor, Steven Berghuis, Steven Bergwijn; and Mohammed Kudus.

JefeBet Prediction

Napoli vs Ajax Predictions Odds Betting Preview October 12, 2022

Napoli is unstoppable. They are not only convincing in the opponent’s zone, but they also play well and have Kvicha Kvarastsjelia in excellent form. Ajax has nothing to fear against the southern Italian team in this Champions League, and even less so on the road.

Prediction: Napoli wins 2 to 1.


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Written by Tomás Yelmini

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