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Arizona Cardinals vs Kansas City Chiefs Predictions, Picks, Odds, and Betting Preview | NFL Week 1 2022

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Kansas City Chiefs running back Derrick Gore (40) during the first half of an NFL football game against the Arizona Cardinals, Friday, Aug. 20, 2021, in Glendale, Ariz. (AP Photo/Rick Scuteri)

Week 1 of the 2022 NFL regular season will feature the Arizona Cardinals vs. Kansas City Chiefs game. This isn’t a divisional or conference matchup, but it’s a fantastic way for both teams to gauge their performance at the start of the season.

The Cardinals didn’t show much in the preseason, which could be due to the fact that the club is still adjusting to their new players. However, the Chiefs also had changes in the team and looked much better in the preparation games. This matchup could reveal the true form of both teams, so it will undoubtedly be an exciting one.

JefeBet brings you today the Cardinals vs Chiefs preview, with an analysis of each team, as well as the prediction and odds available at bookmakers.

Predictions and Betting Preview for the Arizona Cardinals vs Kansas City Chiefs NFL Week 1 Game on September 11, 2022

Cardinals vs Chiefs Predictions Picks Betting Odds
  • Where: State Farm Stadium, Glendale, Arizona.
  • When: Sunday, September 11, 2022, 16:25 PM ET.

Betting on the Arizona Cardinals

Cardinals vs Chiefs Predictions Picks Betting Odds
  • Regular Season Record: 0-0
  • Spread: +4.5
  • Moneyline: +165
  • Over/Under: 53.5

The Arizona Cardinals didn’t look bad in the 2021 season, but their efforts weren’t enough to be first place in the NFC West. They finished in second place with a record of 11-6 and this took them into the wild card round.

However, they were one of the unlucky teams to face the Los Angeles Rams, who eventually became the Super Bowl champions. The Cardinals lost that game 34-11.

Out of the three games the Cardinals played in the preseason, they could only manage one win, which was a 23-36 victory over the Cincinnati Bengals. In terms of offense, they performed well, scoring points in every game, but closed with two straight losses to the Baltimore Ravens by 17-24 and to the Tennessee Titans by 26-23.

Betting on the Kansas City Chiefs

Cardinals vs Chiefs Predictions Picks Betting Odds
  • Regular Season Record: 0-0
  • Spread: -4.5
  • Moneyline: -200
  • Over/Under: 53.5

The Kansas City Chiefs accomplished part of the goal in the 2021 season, as they finished the regular season in first place in the AFC West with a 12-5 record and reached the postseason. In the wild card round, they defeated the Pittsburgh Steelers 42-21, and were crowned in the divisional round with a 42-36 win over the Buffalo Bills.

However, they failed to make it to the Super Bowl again as they were beaten 24-27 by the Cincinnati Bengals in the Conference Final.

The team suffered significant losses during the off-season, but despite this, not much difference was seen in the pre-season games played last August. They started with a 19-14 loss to the Chicago Bears and finished with two straight wins, 24-14 against the Washington Commanders and 17-10 against the Green Bay Packers.

JefeBet Prediction

The Chiefs showed order on offense and defense during the preseason with their starting lineups; in this way, it’s hardly surprising that they are the favorites for this matchup. While Kyler Murray’s offense has plenty of tools to cause problems for Kansas City, Patrick Mahomes’ team should do enough to start the season with a win.

Win for the Kansas City Chiefs.


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Written by Mayra Madrigal

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